Publications Integrative Cardiac Bioelectricity Group

Z. Selimi, J-S. Rougier, H. Abriel and J.P. Kucera.
A detailed analysis of single-channel Nav1.5 recordings does not reveal any cooperative gating. J. Physiol. 2023 DOI

Perspectives from
M. Ben-Johny. Coupled sodium channels: Does it really take two to tango?. J. Physiol. 2023 DOI

Q. Jin, K.Y. Lee, Z. Selimi, D. Shimura, E. Wang, J.F. Zimmerman, R. Shaw, J.P. Kucera, K.K. Parker, J.E. Saffitz, A.G. Kleber.
Determinants of electrical propagation and arrhythmogenesis in arrhythmogenic cardiomyopathy. J. Mol. Cell. Cardiol. 186:71-30, 2023 DOI

K. Horgmo Jæger, E. Ivanovic, J.P. Kucera and A. Tveito.
Nano-scale solution of the Poisson-Nernst-Planck (PNP) equations in a fraction of two neighboring cells reveals the magnitude of intercellular electrochemical waves. PLoS Comput Biol 19:e1010895, 2023 DOI pdf

S. Nayir, S.P. Lacour and J.P. Kucera .
Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures. J. Physiol. in press, 2022 DOI pdf

E. Ivanovic, J.P. Kucera.
Tortuous cardiac intercalated discs modulate ephaptic coupling. Cells 11(21):3477, 2022 DOI pdf

S. Vullo, N. Ambrosio, J.P. Kucera, O. Bignoculo, S. Kellenberger.
Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate. eLIFE 10:e66488, 2021 DOI pdf

E. Ivanovic, and J.P. Kucera.
Localization of Na+ channel clusters in narrowed perinexi of gap junctions enhances cardiac impulse transmission via ephaptic coupling: a model study. J. Physiol. 1-33, 2021 DOI pdf

Perspectives from
Rengasayee Veeraraghavan, Nicolae Moise and Seth H. Weinberg. Sodium channels and the intercalated disk - it is all about location, location, location. J. Physiol. 2021 DOI

S.H. Vermij, H. Abriel, J.P Kucera .
A fundamental evaluation of the electrical properties and function of cardiac transverse tubules. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867: 118502, 2020 DOI

A. Maguy, J.P. Kucera, J.P. Wepfer, V. Forest, F. Charpentier and J. Li.
KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2. JACC 75(17):2140-2152, 2020 DOI pdf

Podcast of the editor:

Perspectives from
M. Boutjdir and P. E. Lazzerini. A Novel Peptide/Antibody-Based Antiarrhythmic Approach to Long QT Syndrome and Beyond. JACC 2020 DOI

A. Maguy, J.P. Kucera, J.P. Wepfer, V. Forest, F. Charpentier, J.Li.
KCNQ1 antibodies: from mechanisms to immunological approach for the treatment of the long QT syndrome type 2. in press, 2020

E. Hichri, Z. Selimi, J.P. Kucera.
Modeling the interactions between sodium channels provides insight into the negative dominance of certain channel mutations. Front. Physiol 11:589386, 2020 DOI pdf

O. Alijevic, O. Bignucolo, E. Hichri, Z. Peng, J.P. Kucera, S. Kellenberger.
Slowing of the time course of acidification decreases the acid-sensing ion channel 1a current amplitude and modulates action potential firing in neurons. Front. Cell. Neurosci. 14:41, 2020 DOI pdf

S.A. De Simone, S.Moyle, A. Buccarello, C. Dellenbach, J.P. Kucera and S. Rohr.
The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes. Front. Physiol 2020 DOI

S.H. Vermij, H. Abriel, J.P. Kucera.
Modeling depolarization delay, sodium currents, and electrical potentials in cardiac transverse tubules . Front. Physiol 10:1487, 2019 DOI pdf

E. Hichri, H. Abriel, J.P. Kucera.
Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc. J. Physiol. 596:563-589, 2018 DOI pdf

Perspectives from
R. Veeraraghavan R, P.B. Radwański. Sodium channel clusters: harmonizing the cardiac conduction orchestra. J. Physiol. in press, 2018 DOI

A. Buccarello, M. Azzarito, F. Michoud, S.P. Lacour, J.P. Kucera.
Uniaxial strain of cultured mouse and rat cardiomyocyte strands slows conduction more when its axis is parallel to impulse propagation than when it is perpendicular. Acta Physiologica 223:e13026, 2018 DOI pdf

J.P. Kucera, S. Rohr, A.G. Kléber.
Review: Microstructure, cell-to-cell coupling, and ion currents as determinants of electrical propagation and arrhythmogenesis . Circ. Arrhythm. Electrophysiol. 10:e004665, 2017 DOI

F. Jousset, A. Maguy, S. Rohr, J.P. Kucera.
Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a Detailed In silico Tissue Structure Model. Front. Physiol 7:496, 2016 DOI

F. Syeda, A.P. Holmes, T.Y. Yu, S. Tull, S.M. Kuhlmann, D. Pavlovic, D. Betney, G. Riley, J.P. Kucera, F. Jousset, J.R. de Groot, S. Rohr, N.A. Brown, L. Fabritz, P. Kirchhof.
PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers. JACC 2016 DOI pdf

Perspectives from
M.H. Gollob. Toward Translation of Genomic Discovery to Clinical Efficacy in Atrial Fibrillation. JACC 68(17), 2016 DOI

Y. Prudat, RV. Madhvani, M. Angelini, NP. Borgstom, A. Garfinkel, HS. Karagueuzian, JN. Weiss, E. de Lange, R. Olcese, JP. Kucera.
Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics. J. Physiol. Epub, 2016 DOI

Perspectives from
Jamie I. Vandenberg and Adam P. Hill. An ‘alternans’ way to quantify arrhythmogenic substrates. J. Physiol. 594.9 (2016):2375–2376, 2016 DOI

J.P. Kucera, Y. Prudat, I.C. Marcu, M. Azzarito, N.D. Ullrich.
Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Front. CellDev.Biol. 3:58, 2015 DOI

H. Swan, M.Y. Amarouch, J. Leinonen, A. Marjamaa, J.P. Kucera, P.J. Laitinen-forsblom, A.M. Lahtinen, A. Palotie, K. Kontula, L. Toivonen, H. Abriel, E. Widen.
A gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias resembling CPVT. Circ Cardiovasc Genet. Circ Cardiovascular Genetics 7:771-781, 2014 DOI

Y. Prudat, J.P. Kucera.
Nonlinear behaviour of conduction and block in cardiac tissue with heterogeneous expression of connexin 43. J. Mol. Cell. Cardiol. 76: 46-54, 2014 DOI

J.P. Kucera.
What makes the heart rhythm so intricate?. Heart Rhythm 11(7):1220-1221, 2014 DOI

V. Sottas, JS. Rougier, F. Jousset, JP. Kucera, A. Shestak, LM. Makarov, EV. Zaklyazmiskaya, H. Abriel.
Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias. J. Cardiovasc. Electrophysiol. 24(9): 1037-46, 2013 DOI

H. Abriel, E. de Lange, JP. Kucera, G. Loussouarn and M. Tarek.
Computational Tools to investigate genetic cardiac channelopathies. Front. Physiol undefined, 2013 DOI

M. Lemay, E. de Lange, J.P. Kucera.
Uncovering the Dynamics of Cardiac Systems Using Stochastic Pacing and Frequency Domain Analyses. PLoS Comput Biol 8:1-14, 2012 DOI

A.A Kondratyev, J.-P. Didon, H. Hinnen-Oberer, M. Lemay, J. P. Kucera, A.G. Kleber.
Virtual Sources and Sinks During Extracellular Field Shocks in Cardiac Cell Cultures Effects of Source-Sink Interactions Between Adjacent Tissue Boundaries. Circ. Arrhythm. Electrophysiol. 5:391-399, 2012 DOI

M. Lemay, E. deLange, J.P.Kucera.
Effects of stochastic channel gating and distribution on the cardiac action potential. Journal of Theoretical Biology 281:84-96, 2011 DOI

E. de Lange, J.P. Kucera.
Alternans resonance and propagation block during supernormal conduction in cardiac tissue with decreased [K+]o. Biophys. J. 98:1129-1138, 2010 DOI

K. Wustmann, J.P. Kucera, I. Scheffers, M. Mohaupt, A.A. Kroon, P.W. De Leeuw, J. Schmidli, Y. Allemann, E. Delacrétaz.
Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension 54:530-536, 2009 DOI

E. DeLange, J.P. Kucera.
The transfer functions of cardiac tissue during stochastic pacing. Biophys. J. 96:294-311, 2009 DOI

K. Wustmann, J.P. Kucera, A. Burow, T. Stuber, B. Chappuis, P. Diem, E. Delacrétaz.
Activation of electrical triggers of atrial fibrillation in hyperthyroidism. J. Clin. Endocrinol. Metab. 93:2104-2108, 2008

S. Petitprez, T. Jespersen, E. Pruvot, D.I. Keller, C. Corbaz, J. Schläpfer, H. Abriel, J.P. Kucera.
Analysis of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovasc. Res. 78:494-504, 2008

A Munteanu, A.A. Kondratyev, J.P. Kucera.
Analysis of damped oscillations during reentry: A new approach to evaluate cardiac restitution. Biophys. J. 94:1094-1109, 2008

A.A Kondratyev, J.G.C. Ponard, A. Munteanu, S. Rohr, J.P. Kucera.
Dynamic changes of cardiac conduction during rapid pacing. Am. J. Physiol. 292: H1796-H1811, 2007

J.G.C. Ponard, A.A. Kondratyev, J.P. Kucera.
Mechanisms of intrinsic beating variablility in cardiac cell cultures and model pacemaker networks. Biophys. J. 92: 3734-3752, 2007

D.I. Keller, J.-S. Rougier, J.P. Kucera, N. Benammar, V. Fressart, P. Guicheney, A. Madle, M. Fromer, J. Schläpfer, H. Abriel.
Brugada syndrome and fever: Genetic and molecular characterization of patients carrying SCN5A mutations. Cardiovasc. Res. 67: 510-519, 2005

S. Rohr, J.P. Kucera.
Cardiac tissue architecture determines velocity and safety of propagation. DP. Zipes, J. Jalife eds. Cardiac Electrophysiology: From Cell To Bedside, 4th Edition 222 - 231, 2004

S.P. Thomas, J.P. Kucera, L. Bicher-Lehmann, Y. Rudy, J.E. Saffitz, A.G. Kléber.
Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ. Res. 92:1209-1216, 2003

S. Rohr, R. Flückiger-Labrada, J.P. Kucera.
Photolithographically defined deposition of attachment factors as a versatile method for patterning the growth of different cell types in culture. Pflugers Arch. 446:125-132, 2003

J.P. Kucera, S. Rohr, Y. Rudy.
Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ. Res. 91, No 12, 1176-1182, 2002

T.J. Hund, J.P. Kucera, N.F. Otani, Y. Rudy.
Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model. Biophys. J. 81:3324-3331, 2001

J.P. Kucera, Y. Rudy.
Mechanistic insights into very slow conduction in branching cardiac tissue. A model study. Circ. Res. 89:799-806, 2001

S. Rohr, J.P. Kucera.
Optical mapping of impulse propagation between cardiomyocytes. In: Opitcal Mapping of Cardiac Excitation and Arrhythmias (Eds. D.S. Rosenbaum, J. Jalife) Futura Pu pp. 113-135, 2001

J.P. Kucera, A.G. Kléber, S. Rohr.
Slow conduction in cardiac tissue: Insights from optical mapping at the cellular level. J. Electrocardiol. 34 suppl 1:57-64, 2001

J.P. Kucera, M.O. Heuschkel, P. Renaud, S. Rohr.
Power-law behavior of beat-rate variability in monolayer cultures of neonatal rat ventricular myocytes. Circ. Res. 86:1140-1145, 2000

A.G. Kléber, J.P. Kucera, S. Rohr.
Principles of slow and discontinuous conduction. Experimental observations. In: Magalev T, Tchou JT, eds. Atrial av nodal electrophysiology: A view from the Millenium. Armonk, NY: Futura Publishing Co; 2000:73-88. 2000

S. Rohr, A.G. Kléber, J.P. Kucera.
Optical recording of impulse propagation in designer cultures. Cardiac tissue architectures inducing ultra-slow conduction. Trends in Cardiovasc Med 9:173-179, 1999

S. Rohr, J.P. Kucera.
Optical recording system based on a fiber optic image conduit: Assessement of microscopic activation patterns in cardiac tissue. Biophys. J. 75:1062-1075, 1998

S. Rohr, J.P. Kucera, A.G. Kléber.
Slow conduction in cardiac tissue, i: Effects of a reduction of excitability versus. A reduction of electrical coupling on microconduction. Circ. Res. 83:781-794, 1998

J.P. Kucera, A.G. Kléber, S. Rohr.
Slow conduction in cardiac tissue, ii: Effects of branching tissue geometry. Circ. Res. 83:795-805, 1998

S. Rohr, J.P. Kucera, A.G. Kléber.
Form and function: Impulse propagation in designer cultures of cardiomyocytes. News Physiol Sci 12:171-177, 1997

S. Rohr, J.P. Kucera.
Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by bay k 8644. Biophys. J. 72:754-766, 1997

S. Rohr, J.P. Kucera, V.G. Fast, A.G. Kléber.
Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 275:841-844, 1997

A.G. Kléber, V.G. Fast, J.P. Kucera, S. Rohr.
Physiologie und Pathophysiologie der kardialen Erregungsleitung. Zeitschrift für Kardiologie 85:25-33, 1996