Publications Cardiac EC-Coupling Remodeling Group
P. Dotti, M. Fernandez-Tenorio, R. Janicek, P. Marquez-Neila,
M. Wullschleger, R. Sznitman, M. Egger.
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging. Cell Calcium 2024 DOI
A deep learning-based approach for efficient detection and classification of local Ca²⁺ release events in Full-Frame confocal imaging. Cell Calcium 2024 DOI
R. Janicek, E.M. Camors, D.M. Potenza, M. Fernandez-Tenorio, Y. Zhao, H.C. Dooge, R. Loaiza, F.J. Alvarado, M. Egger, H.H. Valdivia, E. Niggli.
Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous Ca2+ releases. J. Physiol. 2024 DOI pdf
Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous Ca2+ releases. J. Physiol. 2024 DOI pdf
Perspectives from
S. Hamilton, D. Terentyev. The yellow brick road to understanding the RyR2 signalosome. J. Physiol.
2024 DOI
C. Egger, M. Fernandez-Tenorio, J. Blanch, R. Janicek, M. Egger.
Dual mode of action of IP3-dependent SR-Ca2+ release on local and global SR-Ca2+ release in ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 186: 107-110, 2024 DOI pdf
Dual mode of action of IP3-dependent SR-Ca2+ release on local and global SR-Ca2+ release in ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 186: 107-110, 2024 DOI pdf
H.K. Agarwal, R. Janicek, J. Zhao, K. Sambath, M. Egger, E. Niggli and G.C.R. Ellis-Davies .
The yin and yang of intracellular delivery of amphipathic optical probes using n-butyl charge masking. Chem. Commun. 2022 DOI
The yin and yang of intracellular delivery of amphipathic optical probes using n-butyl charge masking. Chem. Commun. 2022 DOI
on the list of Chemical Communications HOT Articles 2022
R. Lopez, R. Janicek, M. Fernandez-Tenorio, M. Courtehoux, L. Matas, P. Gerbaud, A. M.
Gomez, M. Egger, E. Niggli.
Uptake-leak balance of SR Ca2+ determines arrhythmogenic potential of RyR2R420Q+/− cardiomyocytes. J. Mol. Cell. Cardiol. 170:1-14, 2022 DOI pdf
Uptake-leak balance of SR Ca2+ determines arrhythmogenic potential of RyR2R420Q+/− cardiomyocytes. J. Mol. Cell. Cardiol. 170:1-14, 2022 DOI pdf
R. Janicek, H. Agarwal, A.M. Gómez, M. Egger, G.C.R. Ellis-Davies, E. Niggli.
Local recovery of cardiac calcium-induced calcium release interrogated by ultra-effective, two-photon uncaging of calcium. J. Physiol. 2021 DOI
Local recovery of cardiac calcium-induced calcium release interrogated by ultra-effective, two-photon uncaging of calcium. J. Physiol. 2021 DOI
A. Illaste, M. Wullschleger, M. Fernandez-Tenorio, E. Niggli, M. Egger
.
Automatic Detection and Classification of Ca2+ Release Events in Confocal Line- and Frame-scan Images. Biophys. J. 2018 DOI
Automatic Detection and Classification of Ca2+ Release Events in Confocal Line- and Frame-scan Images. Biophys. J. 2018 DOI
J. Blanch, M. Egger.
Obstruction of ventricular Ca2+ ‐dependent arrhythmogenicity by IP3‐ triggered SR‐Ca2+ release. J. Physiol. 596.18:4323–4340, 2018 DOI
Obstruction of ventricular Ca2+ ‐dependent arrhythmogenicity by IP3‐ triggered SR‐Ca2+ release. J. Physiol. 596.18:4323–4340, 2018 DOI
Perspectives from
R.E. Dixon. The anti‐arrhythmic drIP3 from a leaky SR. J. Physiol.
596.18 (2018) pp 4291–4293, 2018 DOI
M. Wullschleger, J. Blanch, M. Egger.
Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes. Cardiovasc. Res. 2017 DOI
Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes. Cardiovasc. Res. 2017 DOI
M. Wullschleger, S. Aghlmandi, M. Egger, M. Zwahlen.
High Incorrect Use of the Standard Error of the Mean (SEM) in Original Articles in Three Cardiovascular Journals Evaluated for 2012. PLoS ONE 9(10), 2014 DOI
High Incorrect Use of the Standard Error of the Mean (SEM) in Original Articles in Three Cardiovascular Journals Evaluated for 2012. PLoS ONE 9(10), 2014 DOI
T. Horn, N.D. Ullrich, M. Egger.
‘Eventless’ InsP3-dependent SR-Ca2+ release affecting atrial Ca2+ sparks. J. Physiol. 591: 2103-2111, 2013 DOI
‘Eventless’ InsP3-dependent SR-Ca2+ release affecting atrial Ca2+ sparks. J. Physiol. 591: 2103-2111, 2013 DOI
P. Bader, R. Weingart, M. Egger.
Regulation of Cx45 hemichannels mediated by extracellular and intracellular calcium. Springer-Verlag Pflugers Arch. online, 2012 DOI
Regulation of Cx45 hemichannels mediated by extracellular and intracellular calcium. Springer-Verlag Pflugers Arch. online, 2012 DOI
M. Egger, A.A. Domenighetti.
Adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling by angiotensin II. Elsevier Trends in Cardiovasc Med 20:78-4, 2010 DOI
Adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling by angiotensin II. Elsevier Trends in Cardiovasc Med 20:78-4, 2010 DOI
F. Swift, N. Tovsruda, I. Sjaastada, O. M. Sejersteda, E. Niggli, M. Egger.
Functional coupling of α2-isoform Na+/K+-ATPase and Ca2+ extrusion through theNa+/Ca2+-exchanger in cardiomyocytes. Cell Calcium 48:54–60, 2010 DOI
Functional coupling of α2-isoform Na+/K+-ATPase and Ca2+ extrusion through theNa+/Ca2+-exchanger in cardiomyocytes. Cell Calcium 48:54–60, 2010 DOI
K. Gusev, A.A. Domenighetti, L.M.D. Delbridge, T. Pedrazzini, E. Niggli, M. Egger.
Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI
Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI
M. Keller, J.P.Y. Kao, M. Egger, E. Niggli.
Calcium waves driven by "sensitization" wave-fronts. Cardiovasc. Res. 74:39-45 , 2007
Calcium waves driven by "sensitization" wave-fronts. Cardiovasc. Res. 74:39-45 , 2007
M. Keller, C. Pignier, M. Egger, E. Niggli.
F90927: A new member in the class of cardiactive steroids. Cardiovasc Drug Rev 25:210-220 , 2007
F90927: A new member in the class of cardiactive steroids. Cardiovasc Drug Rev 25:210-220 , 2007
C Pignier, M Keller, B. Vié, B Vacher, M Santelli, E Niggli, M Egger, B Le Grand.
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br J Pharmacol 147:772-782, 2006
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br J Pharmacol 147:772-782, 2006
M. Keller, C Pignier, M Santelli, B Vacher, E Niggli, M Egger.
Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006
Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006
N.D. Ullrich, A. Caplanusi, B. Brone, D. Hermans, E. Larivière, B. Nilius, W. Van Driessche, J. Eggermont.
Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at the basolateral, but not apical membrane of Caco-2 cells. Am. J. Physiol. 290:C1287-96, 2006
Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at the basolateral, but not apical membrane of Caco-2 cells. Am. J. Physiol. 290:C1287-96, 2006
S Kantevari, C J Hoang, J Ogrodnik, M Egger, E Niggli, G C R Ellis-Davies.
Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006
Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006
A Momotake, N Lindegger, E Niggli, R J Barsotti, G C R Ellis-Davies.
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006
N. Lindegger, E. Niggli.
Paradoxical SR Ca2+ release in guinea pig cardiac myocytes after ß-adrenergic stimulation revealed by two-photon photolysis of cated Ca2+. J. Physiol. (Lond). 565.3: 801-813, 2005
Paradoxical SR Ca2+ release in guinea pig cardiac myocytes after ß-adrenergic stimulation revealed by two-photon photolysis of cated Ca2+. J. Physiol. (Lond). 565.3: 801-813, 2005
M. Egger, H. Porzig, E. Niggli, B. Schwaller..
Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach.. Cell Calcium 37:233-243, 2005
Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach.. Cell Calcium 37:233-243, 2005
E. Niggli, M. Egger.
Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004
Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004
M. Keller, C. Pignier, E. Niggli, M. Egger.
Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004
Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004
P. Szentesi, C. Pignier, M. Egger, E.G. Kranias, E. Niggli.
Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ. Res. 95:807-813 , 2004
Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ. Res. 95:807-813 , 2004
H. Zhang, D. Noble, M. Cannell, C. Orchard, M. Lancaster, M.R. Boyett, A.V. Holden, M. Saleet Jafri, E.A. Sobie, W.J. Lederer, S.S. Demir, A. Michailova, F. DelPrincipe, M. Egger, E. Niggli, G.L. Smith, C.M. Loughrey, N. MacQuaide. J. Dempster, A.T. Trafford.
Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003
Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003
A.M. Gómez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, M. Egger.
Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002
Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002
P Lipp, M Egger, E Niggli.
Spatial characteristics of sarcoplasmic reticulum Ca2+release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J. Physiol. (Lond). 542.2:383-393, 2002
Spatial characteristics of sarcoplasmic reticulum Ca2+release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J. Physiol. (Lond). 542.2:383-393, 2002
A. Michailova, F. DelPrincipe, M. Egger, E. Niggli.
Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophys. J. 83:3134:3151, 2002
Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophys. J. 83:3134:3151, 2002
B. Schwaller, M. Egger, P. Lipp, E. Niggli.
Application of antisense oligodeoxynucleotides for suppression of Na+ / Ca2+ exchange. Methods Enzymol. 314:454-476, 2000
Application of antisense oligodeoxynucleotides for suppression of Na+ / Ca2+ exchange. Methods Enzymol. 314:454-476, 2000
F. DelPrincipe, M. Egger, E. Niggli.
L-type Ca2+ current as the predominant pathway of Ca2+ entry during INa activation in β-stimulated cardiac myocytes. J. Physiol. (Lond). 527.3:455-466, 2000
L-type Ca2+ current as the predominant pathway of Ca2+ entry during INa activation in β-stimulated cardiac myocytes. J. Physiol. (Lond). 527.3:455-466, 2000
M. Egger, E. Niggli.
Paradoxical block of the Na+ - Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol. (Lond). 523:353-366, 2000
Paradoxical block of the Na+ - Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol. (Lond). 523:353-366, 2000
F. DelPrincipe, M. Egger, E. Niggli.
Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nature Cell Biology 1:323-329, 1999
Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nature Cell Biology 1:323-329, 1999
R. Assandri, M. Egger, M. Gassmann, E. Niggli, C. Bauer, I. Forster, A. Gölach.
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J. Physiol. (Lond). 516:343-352, 1999
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J. Physiol. (Lond). 516:343-352, 1999
M. Egger, A. Ruknudin, P. Lipp, P. Kofuji, W.J. Lederer, D.H. Schulze, E. Niggli.
Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport. Cell Calcium 25:9-17, 1999
Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport. Cell Calcium 25:9-17, 1999
M. Egger, A. Ruknudin, E. Niggli, W.J. Lederer, D.H. Schulze.
Ni2+ transport by the human Na-Ca exchanger expressed in Sf9 cells. Am. J. Physiol-Cell Physiol. 276:C1184-1192, 1999
Ni2+ transport by the human Na-Ca exchanger expressed in Sf9 cells. Am. J. Physiol-Cell Physiol. 276:C1184-1192, 1999
M. Egger, E. Niggli.
Regulatory function of Na-Ca exchange in the heart: milestones and outlook. J. Membr. Biol. 168:107-130, 1999
Regulatory function of Na-Ca exchange in the heart: milestones and outlook. J. Membr. Biol. 168:107-130, 1999
F. DelPrincipe, M. Egger, G.C.R. Ellis-Davies, E. Niggli.
Two-photon and UV-laser flash photolysis of the new caged Ca2+ compound DMNPE-4. Cell Calcium 25:85-91, 1999
Two-photon and UV-laser flash photolysis of the new caged Ca2+ compound DMNPE-4. Cell Calcium 25:85-91, 1999