Publications Functional Signaling and Cardiac Regeneration Group

H. Perdreau-Dahl, David B Lipsett, M. Frisk, F. Kermani, Cathrine R Carlson, A. Brech, X. Shen, A. Bergan-Dahl, Y. Hou, T. Tuomainen, P. Tavi, Peter P Jones, M. Lunde, J Andrew Wasserstrom, J. Laporte, N.D. Ullrich, G. Christensen, J Preben Morth, William E Louch.
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes. Circ. Res. 132(11):e188-e205, 2023 DOI PubMed

F. Kermani, M. Mosqueira, K. Peters, ED. Lemma, K. Rapti, D. Grimm, M. Bastmeyer, M. Laugsch, M. Hecker, N.D. Ullrich.
Membrane remodelling triggers maturation of excitation-contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes. Basic Res Cardiol 118(1):13, 2023 DOI

C.M. Wahl, C. Schmidt, M. Hecker, N.D. Ullrich.
Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases. Int J Mol Sci 23(17):10174, 2022 DOI

W.E. Louch, N.D. Ullrich, M.F. Navedo, N. Macquaide.
Editorial: Nanodomain regulation of muscle physiology and alterations in disease. Front. Physiol 13:1092304, 2022 DOI

F.F. Darche, N.D. Ullrich, Z. Huang, M. Koenen, R. Rivinius, N. Frey, P.A. Schweizer.
Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols. Int J Mol Sci 23(13):7318, 2022 DOI

E. Kiss, C. Fischer, J. Sauter, J. Sun, N.D. Ullrich.
The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes. Int J Mol Sci 23(8):4460, 2022 DOI

A. Remes, A.H. Wagner, N. Schmiedel, M. Heckmann, T. Ruf, L. Ding, A. Jungmann, F. Senger, H.A. Katus, N.D. Ullrich, N. Frey, M. Hecker, O.J. Müller.
AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure. Basic Res Cardiol 116(1):38, 2021 DOI

A. Körner, M. Mosqueira, M. Hecker, N.D. Ullrich.
Substrate Stiffness Influences Structural and Functional Remodeling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Front. Physiol 12:710619, 2021 DOI

N. Silbernagel, A. Körner, J. Balitzki, M. Jaggy, S. Bertels, B. Richter, M. Hippler, A. Hellwig, M. Hecker, M. Bastmeyer, N.D. Ullrich.
Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials 227:119551, 2020 DOI

F. Jiang, F. Mohr, N.D. Ullrich, M. Hecker, Andreas H Wagner.
Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res 383(2):111565, 2019 DOI

K. Schmitt, B. Molfenter, Natalia Koerich Laureano, B. Tawk, M. Bieg, Xavier Pastor Hostench, D. Weichenhan, N.D. Ullrich, V. Shang, D. Richter, F. Stögbauer, L. Schroeder, Bianca de Bem Prunes, F. Visioli, Pantelis Varvaki Rados, A. Jou, M. Plath, Philippe A Federspil, J. Thierauf, J. Döscher, Stephanie E Weissinger, Thomas K Hoffmann, S. Wagner, C. Wittekindt, N. Ishaque, R. Eils, Jens P Klussmann, D. Holzinger, C. Plass, A. Abdollahi, K. Freier, W. Weichert, K. Zaoui, J. Hess.
Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer. Int J Cancer 145(12):3299-3310, 2019 DOI

V. Sottas, CM. Wahl, M.C. Trache, M. Bartolf-Kopp, S. Cambridge, M. Hecker, N.D. Ullrich.
Improving electrical properties of iPSC-cardiomyocytes by enhancing Cx43 expression. J. Mol. Cell. Cardiol. 120:31-41, 2018 DOI

N. Silbernagel, M. Walecki, Martin K-H Schäfer, M. Kessler, M. Zobeiri, S. Rinné, Aytug K Kiper, Marlene A Komadowski, Kirsty S Vowinkel, K. Wemhöner, L. Fortmüller, M. Schewe, Amalia M Dolga, J. Scekic-Zahirovic, Lina A Matschke, C. Culmsee, T. Baukrowitz, L. Monassier, N.D. Ullrich, L. Dupuis, S. Just, T. Budde, L. Fabritz, N. Decher.
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. Faseb J 32(11):6159-6173, 2018 DOI

S. Srimachai, S. Devaux, C. Demougeot, S. Kumphune, N.D. Ullrich, E. Niggli, K. Ingkaninan, N. Kamkaew, C.N. Scholfield, S. Tapechum and K. Chootip.
Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complementary and Alternative Medicine 17:117, 2017 DOI pdf

, Patrick A Schweizer, Fabrice F Darche, N.D. Ullrich, P. Geschwill, B. Greber, R. Rivinius, C. Seyler, K. Müller-Decker, A. Draguhn, J. Utikal, M. Koenen, Hugo A Katus, D. Thomas.
Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells. Stem Cell Res Ther 16;8(1):229, 2017 DOI

M. Sekulic-Jablanovic, N.D Ullrich, D. Goldblum, A. Palmowski-Wolfe, F. Zorzato, S. Treves.
Functional characterization of orbicularis oculi and extraocular muscles. J. Gen. Physiol. 147(5):395-406, 2016 DOI

P. Beauchamp, W. Moritz, J.M. Kelm, N.D. Ullrich, I. Agarkova, B.D. Anson, T.M. Suter and C. Zuppinger.
Development and Characterization of a Scaffold-Free 3D Spheroid Model of Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes. Tissue Engineering 21:8, 2015 DOI

I.C. Marcu, A. Illaste, P. Heuking, M.E. Jaconi and N.D. Ullrich.
Functional Characterization and Comparison of Intercellular Communication in Stem Cell-Derived Cardiomyocytes. Stem Cells 33(7):2208-2218, 2015 DOI

J.P. Kucera, Y. Prudat, I.C. Marcu, M. Azzarito, N.D. Ullrich.
Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Front. CellDev.Biol. 3:58, 2015 DOI

P. Dias, T. Desplantez, Majd A El-Harasis, Rasheda A Chowdhury, N.D. Ullrich, Alberto Cabestrero de Diego, Nicholas S Peters, Nicholas J Severs, Kenneth T MacLeod, E. Dupont.
Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line. PLoS ONE ;9(2):e90266, 2014 DOI

H. Brinks, MN. Giraud, A. Segiser, C. Ferrié, S. Longnus, N. Ullrich, W. J. Koch, P. Most, T. Carrel, H. Tevaearai.
Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. J. Heart and Lung Transplantation 33: 203-210, 2014 DOI

O. Rokach, N.D. Ullrich, M. Rausch, V. Mouly, H. Zhou, F. Muntoni, F. Zorzato, S. Treves.
Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization. Biochem J 455(2):169-77, 2013 DOI

S. Kyrychenko, E. Polakova, Ch. Kang, K. Pocsai, N.D. Ullrich, E. Niggli, N. Shirokova.
Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc. Res. 97:666–675, 2013 DOI

E. Niggli, N.D.Ullrich, D. Gutierrez, S. Kyrychenko, E. Poláková, N. Shirokova.
Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling. Biochimica et Biophysica Acta 1833:866–875, 2013 DOI

T. Horn, N.D. Ullrich, M. Egger.
‘Eventless’ InsP3-dependent SR-Ca2+ release affecting atrial Ca2+ sparks. J. Physiol. 591: 2103-2111, 2013 DOI

C. Gonzales, N.D. Ullrich, S. Gerber, C. Berthonneche, E. Niggli, T. Pedrazzini.
Isolation of Cardiovascular Precursor Cells from the Human Fetal Heart. Tissue Engineering 18:1-2, 2012 DOI

N.D. Ullrich, H.H. Valdivia, E. Niggli.
PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J. Mol. Cell. Cardiol. 53: 33-42, 2012 DOI

N.D. Ullrich, D. Fischer, C. Kornblum, M.C. Walter, E. Niggli, F. Zorzato, S. Treves.
Alterations of excitation-contraction coupling and excitation coupled Ca2+ entry in human myotubes carrying CAV3 mutations linked to rippling muscle disease. Hum Mut 32:309-317, 2011 DOI

N.D. Ullrich, M. Fanchaouy, K. Gusev, N. Shirokova, E. Niggli.
Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. AJP Heart Physiol 297:H1992-H2003, 2009 DOI

Perspectives from
Thomas R. Shannon. Ryanodine receptor Ca2+ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different. AJP Heart Physiol 297:H1965-H1966, 2009 DOI

V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli, N. Shirokova.
Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 458:915-928, 2009 DOI

N.D. Ullrich, A. Krust, P. Collins, K.T. MacLeod.
Genomic deletion of estrogen receptors does not alter the effects of estrogens on Ca influx and contraction in murine cardiomyocytes. Am J Physiol Heart Circ, 294(6):H2421-7. : , 2008

N.D. Ullrich, A. Koschak, K.t. MacLeod.
Oestrogen directly inhibits the cardio-vascular L-type Ca2+ channel Cav1.2. BBRC, 361(2), 522-7. 2007

O. Tolmachov, Y.L. Ma, P. Patel, M. Themis, H. Spohr, N.D. Ullrich, K.T. MacLeod, Y. Kienast, C. Coutelle, N.S. Peters.
Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC Cardiovasc. Disord., 6:25.. : , 2006

N.D. Ullrich, A. Caplanusi, B. Brone, D. Hermans, E. Larivière, B. Nilius, W. Van Driessche, J. Eggermont.
Stimulation by caveolin-1 of the hypotonicity-induced release of taurine and ATP at the basolateral, but not apical membrane of Caco-2 cells. Am. J. Physiol. 290:C1287-96, 2006

N.D. Ullrich, T. Voets, J. Prenen, R. Vennekens, K. Talavera, G.- Droogmans, B. Nilius.
Comparison of functional properties of the Ca2+ activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium 37(3):267-78, 2005