Publications Atrial Fibrillation and Therapeutic Innovation Group

M. Rieger, C. Dellenbach, J. vom Berg, J. Beil-Wagner, A. Maguy & S. Rohr.
Enabling comprehensive optogenetic studies of mouse hearts by simultaneous opto-electrical panoramic mapping and stimulation. Nature Communications 2021 DOI

Featured Article

A. Maguy, J.C. Tardif, D. Busseuil, C. Ribi, J. Li.
Autoantibody signature in cardiac arrest. Circulation 141:1764–1774, 2020 DOI pdf

Perspectives from
L.A. Hancock , G. Nichol. What Explains Unexplained Cardiac Arrest?. Circ. Arrhythm. Electrophysiol. 141:1775–1777, 2020 DOI

J. Béland, J.E. Duverger, E. Petitjean, A. Maguy, J. Ledoux, P. Comtois.
Development of an open hardware bioreactor for optimized cardiac cell culture integrating programmable mechanical and electrical stimulations. AIP Advances online, 2020 DOI

A. Maguy, J.P. Kucera, J.P. Wepfer, V. Forest, F. Charpentier and J. Li.
KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2. JACC 75(17):2140-2152, 2020 DOI pdf

Podcast of the editor:

Perspectives from
M. Boutjdir and P. E. Lazzerini. A Novel Peptide/Antibody-Based Antiarrhythmic Approach to Long QT Syndrome and Beyond. JACC 2020 DOI

A. Maguy, J.P. Kucera, J.P. Wepfer, V. Forest, F. Charpentier, J.Li.
KCNQ1 antibodies: from mechanisms to immunological approach for the treatment of the long QT syndrome type 2. in press, 2020

J. Li, A. Maguy.
Autoimmune channelopathies: questions remain. Nat. Rev. Cardiol. 14(9):566, 2017 DOI

N Salvarani, A. Maguy, S.A. De Simone, M. Miragoli, F. Jousset, S. Rohr.
TGF-β1 (Transforming Growth Factor-β1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity. Circ. Arrhythm. Electrophysiol. 10(5):e004567, 2017 DOI

Perspectives from
Kuljeet Kaur, PhD; José Jalife, MD. Is TGF-β1 (Transforming Growth Factor-β1) an Enabler of Myofibroblast–Cardiomyocyte Cross Talk?. Circ. Arrhythm. Electrophysiol. 10:e005289, 2017 DOI

Perspectives from
G. Gabbiani. . F1000Prime 2017 DOI

F. Jousset, A. Maguy, S. Rohr, J.P. Kucera.
Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a Detailed In silico Tissue Structure Model. Front. Physiol 7:496, 2016 DOI

K.L. Quang, A. Maguy, X.Y. Qi, P. Naud, F. Xiong, A. Tadevosyan, Y.F. Shi, D. Chartier, J.C. Tardif, D. Dobrev, S. Nattel.
Loss of cardiomyocyte integrin-linked kinase produces an arrhythmogenic cardiomyopathy in mice. Circ. Arrhythm. Electrophysiol. 8(4):921-32, 2015 DOI

J. Boudreau-Béland, J.E. Duverger, E. Petitjean, A. Maguy, J. Ledoux, P Comtois.
Spatiotemporal stability of neonatal rat cardiomyocyte monolayers spontaneous activity is dependent on the culture substrate. PLoS ONE 10(6):e0127977, 2015 DOI pdf

Y.K. Iwasaki, T. Kato, F. Xiong, Y.F. Shi, P. Naud, A. Maguy, K. Mizuno, J.C. Tardif, P. Comtois, S. Nattel.
Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model. J Am Coll Cardiol 64(19):2013-23, 2014 DOI pdf

M. Aflaki, X.Y. Qi, L. Xiao, B. Ordog, A. Tadevosyan, X. Luo, A. Maguy, Y. Shi, J.C. Tardif, S. Nattel.
Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts. Circ. Res. 114(6):993-1003, 2014 DOI PubMed pdf

J. Li, A. Maguy, J.E. Duverger, P. Vigneault, P. Comtois, Y. Shi, J.C. Tardif, D. Thomas, S. Nattel.
Induced KCNQ1 autoimmunity accelerates cardiac repolarization in rabbits: potential significance in arrhythmogenesis and antiarrhythmic therapy. Heart Rhythm 11:2092-100, 2014 DOI

G. Sivagangabalan, H. Nazzari, O. Bignolais, A. Maguy, P. Naud, T. Farid, S. Massé, N. Gaborit, A. Varro, K. Nair, P. Backx, E. Vigmond, S. Nattel, S. Demolombe, K. Nanthakumar.
Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. PLoS ONE 9(1):e82179, 2014 DOI PubMed

X. Luo, Z. Pan, J. Xiao, H. Shan, X. Sun, H. Lin, L. Xiao, A. Maguy, XY. Qi, X. Gao, D. Dong, Y. Zhang, N. Wang, Y. Bai, J. Ai, XY. Luo, Z. Wang, Y. Lu and S. Nattel.
miR-26, an endogenous antiarrhythmic microRNA reported by its antiatrial fibrillation effect. J Clin Invest 123(5):1939-51, 2013 DOI

M. Harada, X. Luo, XY. Qi, A. Tadevosyan, A. Maguy, B. Ordog, J. Ledoux, T. Kato, P. Naud, N. Voigt, Y. Shi, K. Kamiya, T. Murohara, I. Kodama, JC. Tardif, U. Schotten, Van Wagoner DR, D. Dobrev, S. Nattel.
Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation 126(17):2051-64, 2012 DOI

S. Makary, N. Voigt, A. Maguy, R. Wakili, K. Nishida, M. Harada, D. Dobrev, S. Nattel.
Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ. Res. 109(9):1031-43, 2011 DOI

K. Nishida, XY. Qi, R. Wakili, P. Comtois, D. Chartier, M. Harada, YK. Iwasaki, P. Romeo, A. Maguy, D. Dobrev, G. Michael, M. Talajic, S. Nattel.
Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation 123(2):137-46, 2011 DOI

T.A. Farid, K. Nair, S. Massé, MA. Azam, A. Maguy, PF. Lai, K. Umapathy, P. Dorian, V. Chauhan, A. Varró, A. AlHesayen, M. Waxman, S. Nattel, K. Nanthakumar.
Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts. Circ. Res. 109(11):1309-18, 2011 DOI

T. Datino, L. Macle, XY. Qi, A. Maguy, P. Comtois, D. Chartier, PG. Guerra, A. Arenal, F. Fernández-Avilés, S. Nattel.
Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins. Circulation. Circulation 2010 DOI

R. Wakili, YH. Yeh, XY. Qi, M. Greiser, D. Chartier, K. Nishida, A. Maguy, LR. Villeneuve, P. Boknik, N. Voigt, J. Krysiak, S. Kääb, U. Ravens, WA. Linke, GJ. Stienen, Y. Shi, JC. Tardif, U. Schotten, D. Dobrev, S. Nattel.
Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ. Arrhythm. Electrophysiol. 2010 DOI PubMed

A. Tadevosyan, A. Maguy, LR. Villeneuve, J. Babin, A. Bonnefoy, BG. Allen, S. Nattel.
Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem 2010 DOI

A.I. De Souza, S. Cardin, R. Wait, YL. Chung, M. Vijayakumar, A. Maguy, AJ. Camm, S. Nattel.
Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure. J. Mol. Cell. Cardiol. 2010 DOI PubMed

K. Nishida, A. Maguy, M. Sakabe, P. Comtois, H. Inoue, S. Nattel.
The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation. Cardiovasc. Res. 2010 DOI

A. Maguy, Le Bouter S, P. Comtois, D. Chartier, L. Villeneuve, R. Wakili, K. Nishida, S. Nattel.
Ion channel subunit expression changes in cardiac Purkinje fibers: a potential role in conduction abnormalities associated with congestive heart failure. Circ. Res. 104(9):1113-22, 2009 DOI

XY. Qi, YH. Yeh, L. Xiao, B. Burstein, A. Maguy, D. Chartier, LR. Villeneuve, BJ. Brundel, D. Dobrev, S. Nattel.
Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ. Res. 103(8):845-54, 2008 DOI

N. Voigt, A. Maguy, YH. Yeh, X. Qi, U. Ravens, D. Dobrev, S. Nattel.
Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc. Res. 77(1):35-43, 2008 DOI

M. Sakabe, A. Shiroshita-Takeshita, A. Maguy, BJ. Brundel, A. Fujiki, H. Inoue, S. Nattel.
Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia. Cardiovasc. Res. 78(1):63-70, 2008 DOI

L. Xiao, P. Coutu, LR. Villeneuve, A. Tadevosyan, A. Maguy, Le Bouter S, BG. Allen, S. Nattel.
Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ. Res. 103(7):733-42, 2008 DOI

S. Nattel, A. Maguy, S. Le Bouter, Y. Yeh.
Arrhythmogenic ion-channel remodeling in the heart ; heart failure, myocardial infarction, and atrial fibrillation. Physiol. Rev. 87:425-456, 2007 DOI

Y-H Yeh, X. Qi, A. Shiroshita-Takeshita, J. Liu, A. Maguy, D. Chartier, Wang Z and Nattel S.
Atrial tachycardia induces remodeling of muscarinic receptors and their coupled potassium currents in canine left atrial and pulmonary vein cardiomyocytes. Br J Pharmacol 2007 DOI PubMed

A. Maguy, B. Burstein, R. Clément, H. Gosselin, F. Poulin, N. Ethier, JC. Tardif, TE. Hébert, A. Calderone, S. Nattel.
Effects of resveratrol (trans-3,5,4'-trihydroxystilbene) treatment on cardiac remodeling following myocardial infarction. J Pharmacol Exp Ther 323(3):916-23, 2007 DOI

A. Maguy, J. Abi-Char, A. Coulombe, E. Balse, P. Ratajczak, Samuel J-L, S. Nattel, SN. Hatem.
Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes. J. Physiol. 582(3):1205-1217, 2007 DOI

M. Sakabe, A. Shiroshita-Takeshita, A. Maguy, C. Dumesnil, A. Nigam, TK. Leung, S. Nattel.
Omega-3 polyunsaturated fatty acids prevent atrial fibrillation associated with heart failure but not atrial tachycardia remodeling. Circulation 116(19):2101-9, 2007 DOI

A. Maguy, TE. Hebert, S. Nattel.
Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc. Res. 69:798-807, 2006 DOI

J.S. Hulot, E. Villard, A. Maguy, V. Morel, L. Mir, I. Tostivint, D. William-Faltaos, C. Fernandez, S. Hatem, G. Deray, M. Komajda, V. Leblond, P. Lechat.
A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination. 15(5):277-85, 2005 DOI PubMed

D. Godreau, R. Vranckx, A. Maguy, C. Goyenvalle, SN. Hatem.
Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5. J Biol Chem 278(47):47046-52, 2003 DOI PubMed

D. Godreau, R. Vranckx, A. Maguy, C. Rücker-Martin, C. Goyenvalle, S. Abdelshafy, S. Tessier, JP. Couétil, SN. Hatem.
Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocytes. 56(3):433-42, 2002 DOI PubMed